PTACH (NCH-51) is a potent HDAC inhibitor with IC50s of 48 nM, 32 nM, and 41 nM for HDAC1, HDAC4, and HDAC6, respectively. It also significantly inhibits various cancer cells with EC50s ranging from 1.1-9.1 μM and augments HIV-1 production in latently infected OM10.1 cells.
- Potent HDAC inhibitor (HDAC1, HDAC4, HDAC6)
- Exerts growth inhibition against various cancer cells
- Elevates acetylated histone H4 and p21WAF1/CIP1 levels
- Augments HIV-1 production in latently infected OM10.1 cells